Ethnopharmacology of Medicinal Plants

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: ?I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes.? Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but ?hits? can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common.

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