Sudarshan Kriya - Sri Sri Ravi Shankar -CANCER TREATMENT.pdf

INTRODUCTION Behavioral or psychological factors such as chronic stress may influence occurrence or progression of cancer through several mechanisms: 1. Influence of stress on natural killer (NK) cells. 2. Poorer repair of damaged DNA. 3. Modulation of apoptosis. 4. Oxidative stress: aggravated by psychological stress Stress and natural killer cells NK cells are the surveillance cells of immune system, capable of destroying tumor cells and infected cells. Stressors have been demonstrated to decrease lymphocyte proliferation and reduce NK cell cytotoxicity(1). Also, the cytokines- interferon ? and interleukin -2 (IL-2) which otherwise enhance NK cells and lymphocyte activated killer (LAK) cell activity get suppressed due to stress(2). Smoking may play a synergistic role (in conjunction with psychological factors) and may further reduce NK cell cytotoxicity. Suppression of NK cells and its functions may lead to onset and/or progression of cancer. Stress and DNA repair Carcinogens induce tumors by damaging cellular DNA(3). Body’s defense processes repair this damage so as to prevent the occurrence of cancer. Ability to repair damaged DNA, however is impaired in those with depression(4). Some of the animal studies have also suggested that stress may alter the DNA repair processes(5). Thus, inability to repair DNA damage may lead to cancer. Stress modulates apoptosis Apoptosis is a genetically programmed process, which leads to alteration in cell structure and eventual suicide. This process helps elimination of damaged cells, which would otherwise induce carcinogenesis; stress, however, impairs this process(6). Oxidative stress: aggravated by psychosocial stress Though oxygen is the most critical nutrient of life, it is also the source of free radicals or reactive oxygen species (ROS). ROS are generated either during the normal metabolic processes of the body or due to external agents such as radiation, ultraviolet light, cigarette smoke, and environmental pollutants such as asbestos, pesticides etc(7,8). ROS provide a state called as oxidative stress, which is aggravated by psychosocial stress(9), and leads to many diseases including atherosclerosis, coronary heart disease (CHD), rheumatoid arthritis, and cancer. An antioxidant is a substance that scavenges ROS. The body is equipped with antioxidant defense in the form of glutathione and antioxidant enzymes such as superoxide dismutase (SOD), catalase and glutathione peroxidase. Balance between the levels of ROS and antioxidant defense in the body would determine as to whether a person remains healthy or suffers from one of the chronic diseases including cancer, as mentioned above. From the foregoing, it is apparent that psychologic stress could induce cancer and/or may cause its progression through a variety of mechanisms including suppression of immune system, faulty repair of DNA, modulation of apoptosis and through aggravation of oxidative stress. Behavioral interventions Behavioral interventions in the form of relaxation techniques have been studied to see if these could improve immune functions and/or antioxidant defense and may have positive effects on patients suffering from cancer. NK cell activity has been demonstrated to increase by many researchers(10, 11)

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